Just last week I was calling for someone to hack up the Wiimote for PC use, and lo-and-behold, it's here!
Hack-a-day gives an overview, Wii Hacks has lots of different hacks, and Bob Somers has even build a Wiimote Drum Machine.
Apparently you grab the GlovePIE program, get yourself a bluetooth sensor, and you're off and running.
If only I had some time to play with this…